![]() The pathological characteristics of the detected cancers were assessed in individuals treated with radical prostatectomy. The area under the receiver operating characteristics curve (AUC) quantified the discriminative ability of the predictors. Age, total PSA, percent free PSA, and digital rectal examination findings represented predictors of prostate cancer at biopsy in logistic regression models. METHODS.īetween 19, 543 men with a PSA ≤2.5 ng/mL were referred for initial prostate biopsy. ![]() ![]() Because identification of these patients represents a difficult task, we assessed the ability of percent free PSA to discriminate between benign and malignant prostate biopsy outcomes in men with PSA ≤2.5 ng/mL. Up to 17% of men with a prostate-specific antigen (PSA) level below the accepted prostate biopsy cutoff of 2.5 ng/mL may have prostate cancer.
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